Acute Mountain Sickness
There is a mention of high altitude illness in the Western States manual of possible medical emergencies during the race. I would like to take a moment to educate you on the PROBABLE occurrence of this event.
There are three terms common in describing high altitude illness. The first is Acute Mountain Sickness (AMS). A progression of this neurological event is High Altitude Cerebral Edema (HACE). The third term is High Altitude Pulmonary Edema (HAPE). This phenomenon is due to the rate of ascent to altitude and the absolute altitude reached. I will not discuss the pathophysiology of AMS, but give you some statistics to further your knowledge.
The highest point in the Western States Endurance Run is 8750 ft. The race starts in Squaw Valley at 6200 ft. During the first five miles of the run, a gain of 2500 ft takes place! Some entrants fly from sea level and drive up to the start immediately prior to the race.
- 20% of unacclimatized persons will develop AMS at 7000-9000 ft. (1850-2750m)
- Higher prevalence in persons under 50 years of age, children equal to adults.
- Physical fitness is not protective against high altitude illness.
- Persons with previous AMS have an increased risk of getting it again.
- Rate of ascent, altitude reached and individual physiology, predispose one to AMS.
Typically the symptoms develop within 6-10 hours, but sometimes as early as 1 hour. The hallmark is headache accompanied by any of the following; gastrointestinal symptoms (nausea and vomiting or loss of appetite), inability to sleep, dizziness, fatigue and sluggishness.
Given the number of race entrants from sea level, this is not a trivial problem. HAPE commonly occurs on the second night and for the time in the high country it is doubtful. HACE is a medical emergency and a progression of AMS, also doubtful due to the absolute altitude of the Western States trail, and the duration of time at this altitude.
Wilderness medicine reviews will advise a drug called acetazolmide (carbonic anhydrase inhibitor) for prevention of AMS. DON’T DO IT. It is a diuretic and can cause changes in the potassium sodium balance. It causes a bad taste in your mouth, tingling and numbness of hands, and dizziness. PREVENTION is the key to not developing this illness.
- Acclimate for three nights at Tahoe prior to the race.
- No sleeping medications or alcohol.
- Encourage good hydration and high complex carbohydrates.
Again, this is a brief summary of a complex and progressive illness. I hope it sparks questions and discussion.
Linda Lee

